Polymers for Pharmaceutical Application--药用高分子材料(中文导读) 下载 pdf 百度网盘 epub 免费 2025 电子书 mobi 在线

　　本教材是编者总结近十年的教学经验，从大量英文原版文献和书籍中选取适合教学大纲要求的内容编写而成，并对关键知识点配以中文导读，便于学生阅读和理解。全书共分6章，主要内容如下：第一章为药用辅料概述；第二章为高分子材料简介；第三章、第四章分别介绍选材于《Handbook of Pharmaceutical Excipients》（Fourth Edition,edited by Raymond C Rowe,Paul J Sheskey and Paul J Weller）中的天然高分子辅料和合成高分子辅料；第五章介绍现代药物输送系统研发中涉及的生物可降解高分子材料；第六章介绍几类新型的高分子药物输送体系，包括：自组装高分子和纳米制剂、药用水凝胶、高分子-药物轭合物、高分子基因载体。

Chapter 1. Introduction to Pharmaceutical Excipients

药用辅料概述

1.1 Definition of pharmaceutical excipients

1.2 What are excipients doing in medicines?

1.3 Quality and safty of excipients

1.4 Relationship between polymers and pharmaceutical excipients

1.5 Specific notes for polymers used in drug delivery system

本章中文导读

References

Chapter 2. Introduction to Polymers

高分子材料概述

2.1 What are polymers?

2.2 Polymer structure and morphology

2.2.1 Molecular weight

2.2.2 Configuration and conformation

2.2.3 Chain structure

2.2.4 Crystalline

2.3 Synthesis

2.3.1 Addition polymerization

2.3.2 Condensation polymerization

2.3.3 Cross-linking reaction

2.4 Characteristic properties of polymers

2.4.1 Thermal properties

2.4.2 Mechanical properties

2.4.3 Viscoelastic properties

2.5 Characterization techniques

2.5.1 Determination of molecular weight

2.5.2 Determination of structure

2.5.3 Differential scanning calorimetry

2.6 Fabrication and processing

2.6.1 Injection molding

2.6.2 Extrusion

2.6.3 Spinning

本章中文导读

References

Chapter 3. Natural Polymers as Pharmaceutical Excipients

天然来源的药用高分子辅料

3.1 Starch and its derivates

3.1.1 Starch

3.1.2 Pregelatinized starch

3.1.3 Dextrin

3.1.4 Cyclodextrin

3.1.5 Sodium carboxymethyl starch

本节中文导读

3.2 Cellulose and its derivates

3.2.1 Microcrystalline cellulose

3.2.2 Powdered cellulose

3.2.3 Methylcellulose

3.2.4 Ethylcellulose

3.2.5 Hydroxyethyl cellulose

3.2.6 Hydroxypropyl cellulose

3.2.7 Hydroxypropyl methylcellulose

3.2.8 Carboxymethylcellulose sodium

3.2.9 Carboxymethylcellulose calcium

3.2.10 Cellulose acetate phthalate

本节中文导读

3.3 Other natural polymers in pharmaceutics

3.3.1 Chitin/chitosan

3.3.2 Alginate and sodium/calcium alginate

3.3.3 Acacia

3.3.4 Xanthan gum

3.3.5 Gelatin

3.3.6 Albumin

本节中文导读

References

Chapter 4. Synthetic Polymers as Pharmaceutical Excipients

合成的药用高分子敷料

4.1 Polymers based on polyvinyl

4.1.1 Polyvinyl alcohol

4.1.2 Polymethacrylates

4.1.3 Polyvinylpyrrolidone (Povidone)

4.1.4 Crospovidone

4.1.5 Carbomer

本节中文导读

4.2 Polymers based on polyether

4.2.1 Polyethylene glycol

4.2.2 Poloxamer

4.2.3 Polysorbates

本节中文导读

References

Chapter 5. Novel Synthetic Biodegradable Polymers as Drug Delivery Carrier

新型可生物降解的合成药用高分子材料

5.1 Introduction

5.2 Polymers based on polyester

5.2.1 Poly(lactic acid) and poly(lactic-co-glycolic acid) copolymers

5.2.2 Polycaprolactone

5.2.3 Poly(β-hydroxybutyrate)

5.3 Other biodegradable polymers

5.3.1 Poly(orthoesters)

5.3.2 Poly(phosphate esters)

5.3.3 Polyanhydrides

5.3.4 Poly(amino acids)

5.3.5 Polyphosphazenes

本章中文导读

References

Chapter 6. Advanced Applications of Functional Polymer in Drug Delivery

功能高分子材料在药物输送中的应用进展

6.1 Hydrogels for pharmaceutical application

6.1.1 Introduction

6.1.2 Preparation of hydrogels

6.1.3 Properties of hydrogels

6.1.4 Pharmaceutical applications of hydrogels

本节中文导读

6.2 Polymer-based nanomedicine and self-assemblying polymers

6.2.1 Introduction to nanomedicine

6.2.2 Micellation of self-assemblying polymers

6.2.3 Biological significance of polymeric micelles

6.2.4 Drug release from polymeric micelles

6.2.5 Examples of polymeric micelles for drug delivery

本节中文导读

6.3 Polymer-drug conjugates

6.3.1 Introduction

6.3.2 Design and development of polymer-drug conjugates

6.3.3 Examples for polymer-drug conjugates

本节中文导读

6.4 Polymers for gene delivery

6.4.1 Introduction to gene delivery

6.4.2 Polymeric vectors

本节中文导读

References

　　郭圣荣，上海交通大学药学院，教授，浙江大学高分子化学与物理专业博士，曾赴美国佐治亚理工大学从事博士后研究。现任上海交通大学药学院药物控制释放技术与医用高分子课题组负责人，博士生导师。兼职上海市医药卫生青年联合会委员，世界中医药学会联合会第一届中药新型给药系统专业委员会常务理事。研究方向为：1.新型药物输送系统制备和体内外表征，如微、纳米尺度药剂，原位凝胶剂，植入剂等；2.新型药用高分子材料的设计、制备、性状和自组装行为，如生物降解性、两亲性、离子性高分子材料；3. 医疗器械与药剂结合，如载药消化道支架等。近5年来已完成和正在承担的国家和省市级研究项目20项，发表研究性论文100余篇，其中SCIE收录论文60多篇。主编专著二本，主译专著一本，参加编写和编译专著多本。申请中国发明专利18项，授权8项。先后获明治乳业生命科学最高奖（杰出奖）、国家科技进步二等奖、上海市自然科学三等奖和中国药学会科技三等奖。

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